Thursday, January 6, 2022

cushing disease | What is the main cause of Cushing disease?

 life expectancy of someone with Cushing syndrome?

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what do you know about Cushing disease? 

Cushing disease may be a condition within which the hypophysis releases an excessive amount of endocrine (ACTH). The hypophysis is associate degree organ of the endocrine system.Cushing’s syndrome may be caused by overuse of corticosteroid medication, as seen within the treatment of chronic bronchial asthma or autoimmune disease (iatrogenic Cushing’s syndrome), excess production of corticosteroid from a tumour within the suprarenal gland or elsewhere within the body (ectopic Cushing’s syndrome) or a tumour of the hypophysis. 

Cushing disease may be a kind of Cushing syndrome. alternative types of {cushing|Cushing|Harvey Cushing|Harvey Williams Cushing|neurologist|brain doctor} syndrome include exogenous Cushing syndrome, Cushing syndrome caused by adrenal tumour, and ectopic Cushing syndrome.


Causes of Cushing disease 


☑️Cushing disease is caused by a tumor or excess growth (hyperplasia) of the hypophysis. The hypophysis is found just under the bottom of the brain. a kind of pituitary tumour known as associate degree nonmalignant tumor is that the most typical cause. associate degree nonmalignant tumor may be a nonmalignant tumour (not a cancer).

☑️With Cushing disease , the hypophysis releases an excessive amount of adrenocorticotropic hormone.(ACTH)  adrenocorticotropic hormone(ACTH)  stimulates production and unleash of corticosteroid, a stress internal secretion. an excessive amount of adrenocorticotropic(ACTH)  hormone causes the adrenal glands to form an excessive amount of corticosteroid.

☑️Cortisol is generally free throughout disagreeable things. It additionally has several alternative functions, including:

☑️Controlling the body's use of carbohydrates, fats, and proteins

☑️Reducing the immune system's response to swelling (inflammation)

☑️Regulating force per unit area and therefore the body's water balance


Symptoms OF Cushing disease 


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☑️Symptoms has been dilated.

☑️Symptoms of Cushing disease include:

☑️Upper body fleshiness (above the waist) and skinny arms and legs

☑️Round, red, full face (moon face)

☑️Slow rate in youngsters

☑️Skin changes that are typically seen include:

☑️Acne or skin infections

☑️Purple stretch marks (1/2 in. or one cm or a lot of wide), called striae, on the skin of the abdomen, thighs, upper arms, and breasts

☑️Thin skin with straightforward bruising, most typically on the arms and hands

☑️Muscle and bone changes include:

☑️Backache, that happens with routine activities

☑️Bone pain or tenderness

☑️Collection of fat between the shoulders (buffalo hump)

☑️Weakening of the bones, that results in rib and spine fractures

☑️Weak muscles inflicting exercise intolerance


Women could have:


☑️Excess hair growth on the face, neck, chest, abdomen, and thighs

☑️Menstrual cycle that becomes irregular or stops


Men could have:


☑️Decreased or no want for sex (low libido)

☑️Erection issues

☑️Other symptoms or issues could include:

☑️Mental changes, like depression, anxiety, or changes in behavior

☑️Fatigue

☑️Frequent infections

☑️Headache

☑️Increased thirst and elimination

☑️High force per unit area

☑️Diabetes (high blood sugar)


Exams and Tests of Cushing disease 


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☑️The health care supplier can perform a physical examination and raise concerning your symptoms.

☑️Tests are done initial to verify there's an excessive amount of corticosteroid within the body, and so to see the cause.

☑️These tests ensure an excessive amount of cortisol:

⏺️24-hour urine free corticosteroid

⏺️Dexamethasone suppression test (low dose)

⏺️Salivary corticosteroid levels (late at midnight and typically additionally early morning)

⏺️These tests confirm the reason behind the high corticosteroid once it's confirmed:

⏺️Blood adrenocorticotropic hormone level

⏺️Brain MRI

⏺️Corticotropin-releasing internal secretion take a look at, that acts on the hypophysis to cause the discharge of adrenocorticotropic hormone

⏺️Dexamethasone suppression take a look at (high dose)

⏺️Inferior petrosal sinus sampling (IPSS) -- measures adrenocorticotropic hormone levels within the veins that drain the hypophysis compared to the veins within the chest


Other tests which will be done embrace any of the following:


⏺️Fasting blood glucose and A1C to take a look at for polygenic disease

⏺️Lipid and sterol testing

⏺️Bone mineral density scan to check for pathology

⏺️More than one screening take a look at could also be required to diagnose Cushing malady. Your supplier could raise you to visualize a doctor UN agency focuses on pituitary diseases.


Treatment:Cushing  disease 


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⏺️Treatment involves surgery to get rid of the pituitary tumour, if doable. when surgery, the hypophysis could slowly begin to figure once more and come back to traditional.

⏺️During the recovery method from surgery, you'll want corticosteroid replacement treatments because the pituitary wants time to start out creating adrenocorticotropic hormone once more.

⏺️Radiation treatment of the hypophysis can also be used if the tumour isn't utterly removed.

⏺️If the tumour doesn't answer surgery or radiation, you'll want medicines to prevent your body from creating corticosteroid.

⏺️If these treatments don't seem to be winning, the adrenal glands may have to be removed to prevent the high levels of corticosteroid from being made. Removal of the adrenal glands will cause the pituitary tumour to urge a lot of larger (Nelson syndrome).


Possible Complications:Cushing disease 


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⏺️Possible Complications has been dilated.

⏺️Health issues which will result from Cushing disease include:

⏺️Blood clots in veins (deep vein thrombosis)

⏺️Compression fractures in the spine

⏺️Diabetes

⏺️High force per unit area

⏺️Infections

⏺️Kidney stones

⏺️Mood or alternative medical specialty issues

⏺️Weight gain

⏺️When to Contact a Medical skilled

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When to Contact a Medical skilled has been dilated.


Call your doctor  if you develop symptoms of Cushing disease .

If you have got had a pituitary tumour removed, decision your supplier if you have got signs of complications, together with signs that the tumour has came back.

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